09 // BIOREACTOR SPECIFICATIONS

Bioreactor Vessel — Controlled Growth Environment

The bioreactor is the manufacturing floor. Every organ, tissue block, and organism chassis produced by Cellular Foundry passes through a controlled growth environment calibrated to mammalian physiological parameters: 37°C, 5% CO2, pH 7.35–7.45, dissolved oxygen at 4–6 mg/L. Three reactor classes cover the full production range. Scaling from BRX-1 to BRX-100 is constrained primarily by oxygen mass transfer: maintaining >4 mg/L dissolved O2 across tissue constructs thicker than 200 μm requires active perfusion through engineered vascular channels, not passive diffusion. This oxygen transport limit is the fundamental scaling challenge in tissue bioreactor engineering.

DESIGNATION CLASS SCALE OUTPUT FOOTPRINT
BRX-1 Bioreactor-1 Personal 1 organ / run (48–72 hr cycle) Desktop (0.6m × 0.4m × 0.8m)
BRX-7 Bioreactor-7 Clinical Full organ set (heart, liver, kidneys, lungs) / 5-day cycle Cabinet (1.2m × 0.9m × 2.1m)
BRX-100 Bioreactor-100 Industrial 100 organs / day continuous production Facility (floor-mounted, 200m² minimum)
TEMPERATURE 37.0°C ± 0.1°C
ATMOSPHERE 5% CO&sub2 / 95% N&sub2 sterile
PRESSURE Positive pressure (+15 Pa above ambient)
GROWTH MEDIUM Synthetic blood substitute (no animal products)
STERILITY CLASS ISO 5 (Class 100) core growth zone
pH CONTROL 7.35–7.45 (continuous inline monitoring)
DISSOLVED O&sub2 40% air saturation (optimized for SBC metabolism)
MEDIA EXCHANGE Continuous perfusion (0.5 reactor volumes/hr)
BRX-100 GROWTH MEDIUM: PROPRIETARY SYNTHETIC BLOOD SUBSTITUTE. ZERO ANIMAL-DERIVED COMPONENTS. FORMULATION CONTAINS HEMOGLOBIN-ANALOG OXYGEN CARRIER, ALBUMIN-ANALOG COLLOID, AND SYNTHETIC CLOTTING FACTOR PANEL. NO SERUM. NO PLASMA.

The BRX-1 targets clinical and research environments: a hospital transplant center can maintain a single BRX-1 unit and produce replacement organs on-demand from a patient's own SBC profile. The BRX-7 targets major transplant facilities and military medical centers, producing complete organ sets on a scheduled cycle for stockpile maintenance. The BRX-100 is the industrial production line: continuous flow, automated quality control, and real-time output to Fermat Logistics cold-chain transport at the loading dock.